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Cocrystal Solubility Advantage Diagrams as a Means to .

Experimental results with indomethacin-saccharin cocrystal and surfactants (sodium lauryl sulfate, Brij, and Myrj) demonstrate the log-linear relationship characteristic of SA–SP diagrams and the dependence of σmax and dissolution area under the curve (AUC) on SA with characteristic maxima at a threshold supersaturation where drug nucleation .

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Influence of Sodium Lauryl Sulfate and Tween 80 on .

cocrystal. Sodium lauryl sulfate (SLS, also known as Sodium dodecyl sulfate, SDS) is an anionic surfactant and Tween 80 (Polysorbate 80) is a nonionic surfactant, both of which have been widely used in various drug dosage forms to control wetting, stability, and solubilisation of hydrophobic

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Investigation of Ternary Phase Diagrams of Carbamazepine .

Jan 17, 2020 · The phase diagrams for carbamazepine (CBZ) and nicotinamide (NCT) in ethanol and ethanol/ethyl acetate mixture were constructed at 298.15 K and 313.15 K under atmospheric pressure using the static method. The solubility of the 1:1 cocrystal is correlated as a function of the cocrystal former (nicotinamide) concentration by a mathematical model based on solubility product theory and .

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(PDF) Influence of Sodium Lauryl Sulfate and Tween 80 on .

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine-nicotinamide (CBZ-NIC) cocrystal solubility and dissolution behaviour has been studied in this work.

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Engineering cocrystal solubility and stability via .

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JP2013530952A - Pharmaceutical composition of co-crystal .

The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib, methods for their preparation and their use as pharmaceuticals, more particularly their use for the treatment of pain. [Selection figure] None

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Drug Solubility: Importance and Enhancement Techniques

Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development .

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Influence of Sodium Lauryl Sulfate and Tween 80 on .

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ–NIC cocrystal was determined by mea.

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Influence of sodium lauryl sulfate and tween 80 on .

Oct 11, 2013 · The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine-nicotinamide (CBZ-NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ-NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer.

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Engineering cocrystal solubility and stability via .

Cocrystal solubility, stability, and eutectic points were investigated as a function of pH and sodium lauryl sulfate concentration for a series of carbamazepine cocrystals in water. The cocrystals represented two stoichiometries (1:1 and 2:1) and four coformers (salicylic acid, saccharin, 4-aminobenzoic acid, and succinic acid) with various .

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Lilly Roy - Senior Scientist - Vertex Pharmaceuticals .

Dec 01, 2012 · •Created aqueous suspensions with Tween 80, sodium lauryl sulfate or Brij 99 that protected cocrystal against transformation to parent drug using a science-based approach.

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FDA Approved Inhalers | Use Inhalers

FDA Approved Inhalers. Inhalers that are approved for use by the Food and Drug Administration (FDA) in the United States can be classified into two categories: metered dose inhalers (MDIs) and dry powder inhalers. Metered dose inhalers are usually used as asthma rescue inhalers or reliever medicines. There are breath-actuated autohalers such as .

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US8871793B2 - Metaxalone cocrystals - Google Patents

US8871793B2 US13/518,177 US201013518177A US8871793B2 US 8871793 B2 US8871793 B2 US 8871793B2 US 201013518177 A US201013518177 A US 201013518177A US 8871793 B2 US8871793 B2 US 8871793B2 Authority US United States Prior art keywords metaxalone cocrystal 2θ acid cocrystal powder Prior art date 2009-12-23 Legal status (The legal status is an assumption and is not .

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Evaluation of Influence of Various Polymers on Dissolution .

The aim of current study was to explore the influence of three commonly used polymers, that is, cellulosics and noncellulosics, for example, Methocel K4M, Kollidon VA/64, and Soluplus, on the phase disproportionation and drug release profile of carbamazepine-succinic acid (CBZ-SUC) cocrystal at varying drug to polymer ratios (1 : 1 to 1 : 0.25) in matrix tablets.

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(PDF) Effect of pH-sodium lauryl sulfate combination on .

Effect of pH-sodium lauryl sulfate combination on solubilization of PG-300995 (an Anti-HIV agent): A technical note . Sodium lauryl sulfate (SLS) is an anionic surfactant widely used in .

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Sodium lauryl sulfatex - ResearchGate

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(PDF) Investigation of the Effect of Hydroxypropyl .

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine-nicotinamide (CBZ-NIC) cocrystal solubility and dissolution behaviour has been studied in this work.

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Engineering cocrystal solubility, stability, and pHmax by .

Engineering cocrystal solubility, stability, and pH max by micellar solubilization Neal Huang. Corresponding Author. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109‐1065 .

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Patent Report: | US10150729 | Tranilast compositions and .

In a solid dosage form, a tranilast complex or cocrystal of the invention may be admixed with at least one pharmaceutically acceptable excipient such as, for example, sodium citrate or dicalcium phosphate or (a) fillers or extenders, such as, for example, starches, lactose, sucrose, glucose, mannitol, and silicic acid, (b) binders, such as, for .

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Oral Sustained Release of a Hydrophilic Drug Using the .

Download Citation | Oral Sustained Release of a Hydrophilic Drug Using the Lauryl Sulfate Salt/Complex | The objective of this study was to establish the key factor of the lauryl sulfate (LS) salt .

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Nevirapine Pharmaceutical Cocrystal: Design, Development .

Maximum solubility and dissolution rate were observed with cocrystal prepared using saccharin sodium. Cocrystallization leads to increased solubility and improved in vitro dissolution of .

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(PDF) Cocrystal solubility-pH and drug solubilization .

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate - Mass action model for data analysis and simulation to improve design of experiments

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The effect of surfactant and polymer on solution stability .

May 01, 2019 · The thermodynamic solubility of cocrystal was determined in phosphate buffer solution (pH = 6.8) and in the presence of different concentrations of sodium lauryl sulfate (SLS) and polyvinylpyrrolidone (PVP), followed by investigating their effects on solution stability of cocrystal.

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Influence of Sodium Lauryl Sulfate and Tween 80 on .

The influence of the surfactants of sodium lauryl sulfate (SLS) and Tween 80 on carbamazepine–nicotinamide (CBZ–NIC) cocrystal solubility and dissolution behaviour has been studied in this work. The solubility of the CBZ–NIC cocrystal was determined by measuring the eutectic concentrations of the drug and the coformer.

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